Avondlezing door prof.dr. Michel Eppink, georganiseerd door de Bossche Chemische Kring.
Affordable medicines: What will bring the future in bioprocessing!
Samenvatting
Biopharmaceutical proteins are at the core of many high-value therapies for oncology, inflammatory and autoimmune diseases.
As product modalities become more complex and demand continues to grow, manufacturing efficiency has emerged as a key determinant of both commercial success and patient access.
Reducing cost of goods while ensuring quality, robustness, and regulatory compliance is therefore a critical industry priority.
Future competitiveness in biomanufacturing will depend on a deep, molecular-level understanding of bioprocesses translated into streamlined, end-to-end production platforms. Leveraging this insight enables rational process design, improved yields, reduced variability, and simplified operations across the entire value chain—from cell line development and upstream processing to downstream purification and final drug product.
For modalities such as monoclonal antibodies, antibody–drug conjugates, and next-generation recombinant proteins, lean process architectures and integrated control strategies will be essential.
Embedding sustainability principles into manufacturing design will not only reduce environmental footprint but also drive long-term operational efficiency, supporting scalable and affordable production of biopharmaceutical medicines worldwide.
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